Return Styles: Pseud0ch, Terminal, Valhalla, NES, Geocities, Blue Moon.

Pages: 1-

Resveratrol

Name: Anonymous 2010-02-10 11:18

Supposedly this molecule increases longevity. It works in an interesting fashion.

Behold:

The body responds to reduced calorie intake by activating a gene that increases lifespan to outlive the famine. This has been tested on mice, flies and yeast. Resveratrol supposedly mimicks the gene.

What do you think? The panacea for death or a load of hogwash.

Name: Anonymous 2010-02-10 19:18

Neither. Biochemistry is ridiculously complicated and things like this tend to be taken WAY out of context by the media and wishful thinkers.

I have not yet seen anything making the claim you've made, so I'd appreciate a citation. That said, from what I gather, tests on using resveratrol for life extension have had mixed results at best.

Wikipedia:
The groups of Howitz and Sinclair reported in 2003 in the journal Nature that resveratrol significantly extends the lifespan of the yeast Saccharomyces cerevisiae.[3] Later studies conducted by Sinclair showed that resveratrol also prolongs the lifespan of the worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster.[4] In 2007, a different group of researchers was able to reproduce Sinclair's results with Caenorhabditis elegans,[5] but a third group could not achieve consistent increases in lifespan of D. melanogaster or C. elegans.[6]
In 2006, Italian scientists obtained the first positive result of resveratrol supplementation in a vertebrate. Using a short-lived fish, Nothobranchius furzeri, with a median life span of nine weeks, they found that a maximal dose of resveratrol increased the median lifespan by 56%. Compared with the control fish at nine weeks, that is by the end of the latter's life, the fish supplemented with resveratrol showed significantly higher general swimming activity and better learning to avoid an unpleasant stimulus. The authors noted a slight increase of mortality in young fish caused by resveratrol and hypothesized that it is its weak toxic action that stimulated the defense mechanisms and resulted in the life span extension.[7]

http://en.wikipedia.org/wiki/Resveratrol#Life_extension

Name: Anonymous 2010-02-10 20:17

Yeah they think Reservatrol is the key to the "French paradox".


But they always have something new like this. A lot of the old compounds that they did rat studies on have had doubt cast on them because they found out that some things increased the life spans of lab rats (basically nasty inbred shitty rats) but had no effect on wild rats.

Also there are plenty of compounds reputed to show life extension, I for one would be more interested in what comes of the new genetic engineering stuff they have been doing with worms.



One thing I would like to note if you are interested in this is M-foundation they offer a million dollar prize for proven life extension...

Name: Anonymous 2010-02-11 3:37

Supposedly resveratrol modulates SIRT1 activity, downregulating p53 activity and therefore lessening apoptosis.


Seems to me that would put you at an increased risk for cancer, but I dunno.


Anyways, it's not the panacea for death.

Name: Anonymous 2010-02-11 12:47

Name: Anonymous 2010-02-12 3:48

bump past spam

Don't change these.
Name: Email:
Entire Thread Thread List