Not really. 3D invokes expectations of a 3D environment. Being able to climb over things, manipulate whatever you want, etc. Look at all the fire a 3D game that doesn't allow this draws, especially in the post-stealth/espionage era of 3D. Expectations for ingame widgets and doodads are riding very high unless the game bills itself as being ridiculously cartoony beforehand. (Unreal for instance.)
I know Fallout is pretty intensive but I've never played the other two since they're tied to that crappy D&D thing, so I don't know about those.
I know that Jagged Alliance would make the jump reasonably well though. Would be like squad-based MGS.