Spore.

http://www.pqhp.com/cmp/gdctv/
Video near bottom, you should probably use a spamfilter-address for the registration process.
This game looks like awesome.
Will Wright is actually funny?

At first I thought it looked cool. Then, the more I thought about it, the more I realized that there were two potentially huge issues with the design that I doubt Will Wright can resolve.

The first big one is that there is not just one game here, but many different games, one for each playable scale. The idea that progressing through each stage is like a "tutorial" is kind of depressing; what reason do you have to go back to the beginning? There are some interesting things to do in some of the scales, and they have an effect on later ones, but it doesn't look anywhere near as interdependent and difficult-to-balance as what's in Simcity or the Sims, which robs it of all the intellectual charm; you can build different creatures with different attributes, but what makes one better than another? Will we see real environmental difference and adaptation? Or are all they all made "equal" by design, with the difference being only a combative one? (the latter was my impression) The numerical aspects of the Sims and SC play a big role to me; things like population or wealth or happiness are fun to measure and to try to improve on, but there seems to be a lack of those measures in Spore.

The second problem is with the endgame; it's pure sandbox, but the things you can do seem pretty limited. You can go around and invade or blow up other planets, and that's the most you'll ever do to interact with other players - and it's a one-way interaction since you're invading a local copy of their planet, not the "real thing." I can't see myself being addicted to that gameplay for very long.

But then, he might well have come up with ways to resolve these issues that I can't see from behind the press release smokescreen.