Best Python Framework?

I haven't done much web development yet, what's the best framework to use in your opinion?
I kind of like the syntax of webapp2, in GAE, but I'm scared of being too restricted.

1. https://en.wikipedia.org/wiki/Comparison_of_web_application_frameworks#Python
2. MVC types. Usually I just stick with document generators like WML and org-mode. When I need to program something, I use Perl at first, then I optimize it on C; mawk if I need scripting.
IOW, I do not use FOIC.

They kids say they like Django, and other that are forced to use FOIC use TurboGears. But it would not be my recommendation.