There is a cultural difference between high- and low-level programmers. An assembler programmer writes his memory manipulations using cleverly crafted and utterly indisernible logic operations. 30 minutes later he himself doesn't understand what he's written.
A Python- or C-coder strives for structure and such utter nonsense thus nullifying the miniscule difference between low-level and compiler-compiled code. All in all, the assemblists code is probably faster - if only it takes three times as long to write and debug.