IRC Clients / Scripts

So.. out of all the IRC clients, scripts and addons, is there one setup that is commonly known as being pretty much awesome for most purposes?

I've been using mIRC + Anaconda for a while, and it's nice and tidy, but I hear Sysreset is pretty handy.

Any suggestions?

Fuck no, not irssi.

Irssi is awesome as a pure client, especially in you're using a remote box. But if you want to serve files, stick to mIRC + Sysreset. Irssi's serving scripts are quite poor, particularly ones you can navigate. I haven't seen any decent autovoicers either.