What newspaper strip could be a series?

Yes, you have things like Dilbert that try to eek out enough jokes to fill in half an hour, but then you have shows that capture and sometimes exceed their newspaper counterparts.  Garfield brings more personality than its tired counterpart, and Dennis the Menace creates a backdrop that could never fit in a single panel (albeit for kids only).  So what strips could be fully animated, even if they were microseries like 5-15 minutes each if half an hour was too long? 

Doonesbury? 

Cathy had a commercial for some wholesale clothing store. I have no idea why I remember this, but it made me realize how fucking bad an actual Cathy cartoon would be.
"WAHHHH WAAHHHH I'M TOO FAT NO ONE APPRECIATES MY HARD WORK WITTY SOCIAL COMMENTARY BLAHHH..."
For 30 minutes. My brain hemorrhages  at the thought of it.